Both charge at the same time and using Anima Sola chains both in the same spot, Significantly increases damage by +21.6, however the damage boost wears off slowly over time at a rate of roughly -0.04 per second, Every enemy you kill adds +0.02 Damage to the timed effect of Red Stew, UNLOCK: Unlock this item by defeating Satan as Jacob & Esau, When used, removes all your passive items and teleports you to Isaac's Bedroom, For every passive item removed, you are given a choice of 3 random pedestal items from any item pool. To help with range, the orbit is now also offset based on the current direction Isaac is shooting, * item room, treasure room, item room pool, grey, gray, asteroid, silver, ball, Creates a friendly blue spider when you kill an enemy, Spiders are spawned at the location where the enemy died, * item room, treasure room, item room pool, pink, smile, E. Coli turns normal enemies into poop if they touch you, Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage, Can be combined with Midas Touch to turn enemies into Golden Poop, This does not work on mini-bosses and bosses. DQY7 QK7M (The Basement XL: Second boss's Devil Room), PC QFJL Q6SC (One of the chests in Curse Room adjacent to spawn), PC QW44 N10D (Second floor Devil Room; Isaac may proceed normally, but all other characters must not enter the first floor Treasure Room. If a devil deal was already taken this run, it spawns 2 soul hearts and 1 Angel Room item instead. REPENTANCE - The Lost's Holy Mantle can no longer be re-rolled using an item like D4. The Lost starts with this item after donating 879 coins to the Greed Donation Machine. Pickups * e coli, item room, treasure room, item room pool, tampon, bloody, red, white, red sperm, ecoli, Isaac's tears turn into large scythes that pierce through enemies (Similar to how Death's scythes look), UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka), * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, axe, silver, The Knife Piece 1 is located in the Item Room in the mirrored area. REPENTANCE - White Pony's charge time has been reduced to 2 (from 6). Isaac appears demonic with large curved horns and an angry expression. syringe, needle, injection, purple, grey, gray, Causes Isaac to shrink in size (including hitbox slightly), Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms, * item room, treasure room, item room pool, mushroom, blue, spotted, Adds several instances of The Bible item into all item pools. Unlocked by beating Isaac with Samson. Trinkets Cain has a 50% chance of firing a shot with the effects of Chemical Peel whenever he fires. It can take you to rooms that require bombs/keys, e.g. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. Objects Items The signals tell your spleen to release . This can be anything that would normally drop from a chest including pedestal items, When used, this item causes Isaac to become humongous for 30 seconds, While huge, Isaac is invincible and can crush objects, doors and enemies, For the duration of the effect this gives you a x4 Damage Multiplier and +2.0 Range Up, but your rate of fire goes way down. Heart - 26.6% chance, Trinket - 6.6% chance. Tulsa pop star talks about blood clot awareness at Capitol. The effect is shown visually in 3 stages with the character's belly getting larger each time until it finally gives birth to a familiar. Magdalene . Corpse II drops same as Womb II, UNLOCK: Unlock this item by beating the Dark Room with Lazarus, * red chest pool, red chest item pool, shop room pool, shop item pool, blue box, pandoras box, When used, turns Isaac invincible and gains +0.28 speed for a 5 seconds, You cannot fire tears while the stump is active, Very similar to the My Little Unicorn item but does not deal contact damage, When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active, * item room, treasure room, item room pool, white, lump, grey, gray, blob, While in a hostile room your speed raises at a rate of +0.065 per game tick, When you hit a speed stat of 2.0, Isaac will gain an invincibility effect for 5 seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit, The time it takes for the effect to activate becomes shorter with a higher base Speed stat, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, horns, Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed, Will not deal contact damage unless you are moving fast enough (at least 0.8 speed), REPENTANCE - Aries now prevents receiving contact damage if ramming and killing enemies at full speed, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, glow, After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken), * astrology, astronomy, item room, treasure room, item room pool, cyan, black, the lost item pool, starting, bloody, white, bandages, lazarus rags, Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms, UNLOCK: Unlock this item by beating Satan with The Lost, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, If Brimsnap is used and it coincides with. Ultra Secret RoomTreasure RoomTreasure Room The stationary head is now affected by Isaac's stats and attack modifiers, and the body will spew a controllable fountain of blood shots. e.g. Isaac's touch now petrifies enemies, turning them to gold for a few seconds. Also works for opening Spiked Chests and Mimic Chests without taking damage, When used, this item restarts the game and places you back on the first floor with all your currently collected items, similar to doing a Victory Lap, Allows angel rooms to be found in the new run if a devil deal was taken in the first run, In Greed Mode and while playing as Tainted Keeper, this item costs 99 coins instead of 15. 5c pickups become 3c. No longer reduces your devil/angel room chances when used, * item room, treasure room, item room pool, the lost item pool, bomb, tnt, clock, red, When used, causes all enemies in the current room to run away from Isaac in fear for 5 seconds. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, UNLOCK: Unlock this item by defeating The Beast as ??? or The Lamb, it will die instantly, Can also be thrown against a door to open it (Doesn't work against Mega Satan's door). Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. box, yellow, grey, When used, converts 1 soul/black heart into 1 red heart container, This item will take from your soul hearts first, REPENTANCE - Converter now only costs one soul heart to use (previously costed two), * shop room pool, shop item pool, the lost item pool, blue, gray, grey, yellow, sprocket, When used, this item will spawn a set of items or consumables based on which chapter you are currently on, Basement 1: 2 Soul hearts. Starts at +3.6 damage and goes to 0 after 30 seconds, While this temporary damage boost is active, each enemy you kill increases your damage slightly, allowing you to quickly kill multiple enemies and chain the effect for longer, This item also gives a -0.03 Speed Down for every food item held. white, brown, underwear, moms bra, mom bra, Causes an explosion near Isaac which takes away half a heart and does 40 damage all enemies in close proximity, REPENTANCE - Kamikaze now has increased blast damage and radius. Bosses REPENTANCE - White poop from Hallowed Ground is now more durable, similar to golden poop. If a pushed enemy hits a rock or wall forcefully enough, they take 10 damage, UNLOCK: Unlock this item by destroying 100 poops, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, ?, Satan and The Lamb as Tainted Bethany, Taking damage gives you a chance to spawn a flame orbital, similar to the ones created by Book of Virtues, Entering an Angel Room gives you +5 flame orbitals. Mulligan can be hit by enemy projectiles, making him a good shield, Enemies will sometimes target the Mulligan if he is closer, * item room, treasure room, item room pool, sad, baby, lumpy, brown, pink, When used, makes Isaac leap in the air, similar to the leaper enemies, Maintains momentum if you are already moving in the same direction, If you already have an item which gives you flying, this item becomes a dash effect instead, Can be used in the Isaac boss fight to jump over the beams of light he spawns, * library pool, library room, book room pool, item room, treasure room, item room pool, The laser deals damage equal to Isaac's damage and deals damage each tick. The laser hits up to 13 times if an enemy stays inside it for the duration, Has a chance to drop from the Envy and Super Envy miniboss fights, Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss, * item room, treasure room, item room pool, red, lips, white, eyes, UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss, *, black, white, face, eyes, mouth, golden chest pool, +10% chance of a devil/angel room opening while held, A second Pentagram will give an extra +5% chance, Counts as 1 of 3 evil items needed towards the Leviathan transformation, Item Pool: Boss Room, Curse Room, Devil Room, Demon Beggar, Crane Game, * curse room pool, devil pool, devil room pool, devil deal, boss room pool, boss room item, It can only be fired after a short charge-up period (approximately 1-2 seconds until Isaac's head begins flashing red). When used, the D12 re-rolls any rocks into another random type of object (e.g. Brimstone is a passive item. Lil Clot is an unlockable trinket added in The Binding of Isaac: Repentance. Seeds Trinkets You have the Holy Mantle effect to prevent one hit per room, but taking another hit will kill you. For example if the spawned boss leaves creep, it can damage Isaac, UNLOCK: Unlock this item by defeating Delirium for the first time on any character, A familiar fly that orbits around a random enemy in the room until that enemy dies, dealing 2 contact damage to other enemies, Angry Fly will move to the next enemy after the one it is currently orbiting dies, until the room is cleared, at which point it will return to orbiting Isaac, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Custom Phase, UNLOCK: Unlock this item by transforming into Beelzebub (Achieved by picking up 3 fly related items, see Transformations page for full list), A throwable active item that places a black hole on the ground where it lands, sucking all enemies into it for 6 seconds, Enemies stuck inside the black hole take rapid damage over time, The Black Hole will also suck Isaac into it, but with a much weaker effect than to enemies, The Black Hole will destroy nearby obstacles such as rocks and pots, Adds a random chance for an enemy in the current room to become charmed or feared briefly, Adds a random chance to spawn a rainbow poop upon taking damage, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Electoon, UNLOCK: Unlock this item by breaking 5 rainbow poops, *, red, white, stripe, hat, clown, waldo, wally, Causes random enemies to 'lag' at random intervals, causing them to freeze in place for a second, The lag effect can also apply to tears, projectiles and consumables on the ground, While held, this item has a 25% chance to double up any end of room drops (similar to the Contract from Below effect), Isaac's Luck stat affects how often the lag effect occurs, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Freezenification, UNLOCK: Complete 7 Daily Challenges (30 on console), A one-time use item that spawns a random item from the current room's item pool, with a chance for it to spawn Lump of Coal or The Poop instead, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Mills, *, green, red, present, bow, xmas, christmas, When used, spawns a Sprinkler that rotates in a circle, spraying tears in all directions, Will also synergize with some other items, such as Mom's Eye, Brimstone, Dr. Fetus, Tech X or Loki's Horns, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Kieran and Stewartisme, Allows you to rapidly place bombs on the ground, Added as part of the Afterbirth+ Booster Pack #1. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) Attributes Monsters white, red, moms eye, mom eye, When used, drops a pool of 'lemonade' on the floor which damages any enemies that come into contact with it for 8 damage per tick, * item room, treasure room, item room pool, yellow, chet lemon, Gives Isaac an orbiting fly which deals 5 contact damage to enemies per tick, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, If the enemy dies while in this state they will drop 1-4 coins, Rainbow poop Dips charm enemies and have a chance to spawn 1/2 a red heart on death. On average, they deal 66% damage. PC 9SS3 3YXY (Second floor treasure room) (+ Technology 2 on third floor), PC GXSE V7P4 (Treasure Room adjacent to spawn), PC EZTZ CL68 (Treasure Room adjacent to spawn), PC RR0G KKQJ (Treasure Room adjacent to spawn), PC 6FDS 6FWF (Treasure Room adjacent to spawn), PC PCM8 R3H4 (Treasure Room adjacent to spawn), PS4 GXA1 L6XC (Treasure Room adjacent to spawn), PS4 27T2 26G0 (First floor Treasure Room), 3DS 11DA E0JZ (Treasure Room adjacent to spawn), Switch AL2T Q6NC (First Golden Treasure Room), Achievements Items Upon use, this item summons a ghost near Isaac that will follow him around. While in this form you can walk over enemies to mark them for death. Tears have a 50% chance to be Blood Clot tears. Blood Clot - Unless playing as Cain, no damage or range bonus will be given from the item, as the blood clot covers the other eye. ), UNLOCK: Unlock this item by beating Blue Womb (Hush) with Cain, Gives Isaac a familiar golden Censer which creates a huge aura of light that slows down any enemies inside it, UNLOCK: Unlock this item by beating Greed Mode with Maggy, A familiar beggar similar to Bum Friend that follows Isaac and collects keys, giving random chests in return, UNLOCK: Unlock this item by beating Greed Mode with Lazarus, Item Pool: Item Room, Secret Room, Key Beggar, *, grey, gray, black, face, stone, rock, baby, A bag that follows Isaac and drops a random Rune or Soul Stone every 7 or 8 rooms, UNLOCK: Unlock this item by beating the Isaac boss with Lilith, A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate, Item Pool: Item Room, Angel Room, Greed Mode Angel Room, This item causes enemy projectiles to be able to hit other enemies. The heart is a less common location for a blood clot, but it can still happen. Rooms The attack can be released only when fully charged. When you take the reverse path back up to Home, the trinket will turn into Cracked Key in the same floor/room you dropped it before. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. This means you need a way to teleport out of the Mom's Foot boss fight. Bad Trip becomes Balls of Steel. Tainted Eve is unlocked by reaching Home and using the Red Key, Cracked Key, or Soul of Cain to access a special room in one of the walls while playing as Eve. Isaac. (D20 effect), 3 Dot - Rerolls all pickups on the entire floor, 4 Dot - Rerolls all pedestal items on the floor. 25 Of The Best Items In The Binding Of Isaac. Clot Clots crawl in random directions, shooting 4 tears horizontally . 5.100.229 in The Chest as Apollyon, Upon entering a room with enemies, spawns a Black Locust that deals quadruple Isaac's damage, applied as two hits of double damage, UNLOCK: Unlock this trinket by defeating The Lamb as Apollyon, At the start of each new hostile room you spawn 2-5 white attack flies, which will target a nearby enemy and deal double your tear damage to it, UNLOCK: Unlock this trinket by defeating Boss Rush as Apollyon, When killing an enemy, you have a very small chance to gain the ability to fly for the rest of the room, UNLOCK: Unlock this trinket by defeating Greedier Mode with Azazel, Stem Cell heals Isaac's red heart containers to 50% each floor, If Isaac already has 50% health or more, it heals half of a heart instead, UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson, Fully recharges your active item at the start of each boss fight, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Zaratus, Gives you the Holy Mantle shield effect at the start of every new floor, which protects you from the next hit of damage you take, Does not recharge until the start of the next floor, Stacks with the effects from Holy Mantle and Blanket, but it does not stack with Holy Card, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ep and Mills, Using your active item while holding this trinket will drop it back on a pedestal on the ground, Also after taking damage, you have a very small chance to drop one of your passive items, One-time use active items will be consumed and not dropped, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by MarkusLeben and iguesti, *, yellow, golden, box, block, square, cube, Holding this trinket will cause the Angel mini bosses to drop normal items instead of Key Pieces, Added as part of the Afterbirth+ Booster Pack #2, designed by Edmund McMillen, While held, the last door Isaac went through stays open, allowing him to leave the room even if enemies are in it, This trinket works on boss rooms (except Ultra Greed) and devil rooms containing Krampus, allowing you to exit out mid-fight, UNLOCK: Unlock this trinket by blowing up doors and secret room walls 50 times, *, door, stop, wedge, cheese, wood, brown, hodor, game of thrones, Wylis, After being picked up, a yellow laser chain now flows through Isaac's familiars, Added as part of the Afterbirth+ Booster Pack #4 and based on the Steam Workshop mod created by Strawrat and Aczom, While held, spawns +1 friendly blue fly every time you pick up a coin, Added as part of the Afterbirth+ Booster Pack #5. *, brown, red, tup, carton, box, golden chest pool, gold chest pool, Item Pool: Boss Room, Gold/Stone Chest, Mom's Chest, *, white, necklace, grey, gray, moms pearls, mom pearls, The Car Battery causes your spacebar item to activate twice on each use, For example, with Yum Heart you would heal 2 full red hearts instead of 1, Upon use, gives you a duplicate of each familiar you have for the current room, It will not 'double' your familiars as the tagline suggests - if you have 2 of one kind, it will only give you an extra one, If the familiar only appears when taking damage (i.e. Further Reading: The Binding of Isaac: Repentance Review; Version 1.78 brings with it a plethora of gameplay changes, which we know you're itching to check out. 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