The safety and effectiveness of benzonatate in children below the age of 10 years have not been established. Benzonatate benzonatate capsule. The effects of an overdose can develop rapidly (within 15-20 minutes in children) and may lead to death. North Carolina Office of the Chief Medical Examiner, Raleigh, NC. How Does Respiratory Syncytial Virus (RSV) Spread? Sucking or chewing the capsule may cause serious side effects. We avoid using tertiary references. Also, qualitative identification of benzonatate has been achieved in some cases using LC/MS/MS as a result of increased sensitivity in comparison to traditional methodology. The Medical Letter authors conclude when a cough suppressant is truly necessary, dextromethorphan or even codeine might be a safer choice. When codeine compares favorably in safety to another medicine, it might be time to reconsider why we ever use it. Overdose of benzonatate has been reported in adults and adolescents. You should not need a new prescription for this medication to be refilled. Food and Drug Administration. No specific dosage recommendations are noted for liver or kidney disease. The safety and effectiveness of benzonatate in children under 10 years of age have not been established. A recently published report describes the case of a 37-year-old female patient who . Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Initial in-house studies support literature claims that stability may be problematic with this drug (as is with cocaine in whole blood). Not every pharmacy stocks this drug. (2016, December 6). It acts peripherally on stretch receptors in the lower respiratory tract to suppress the cough reflex. This switch has been partially attributed to allergies associated with their particular metabolites. Im a doctor, but Im not your doctor despite the fact that you read or comment on my posts. Benzonatate is a polyglycol derivative structurally related to procaine and tetracaine. Talk to your doctor if you breastfeed your child. Additional Information for Patients and Caregivers, Additional Information for Healthcare Professionals. This information is not a substitute for medical advice. Signs and symptoms of overdosage include tremors, convulsions, coma, and heart attack. Here are eight air purifiers we recommend for dust and allergies. Follow all directions on your prescription label and read all medication guides or instruction sheets. Review/update the If the capsules are chewed, then release of benzonatate from the capsule in the mouth can produce a temporary numbing of the mouth and choking could occur. Benzonatate is used to relieve coughing. Copyright 2023 IBM Watson Health. Advertising revenue supports our not-for-profit mission. Swallow the pill whole. Is It Possible to Get RSV More Than Once? You can get RSV twice or even more often than that. The maximum dosage is 600 mg/day. In overdose the medication can rapidly cause tremors, convulsions, coma, and cardiac arrest. Taken in overdose, benzonatate can rapidly cause seizures, cardiac arrhythmias and death. In-house analysis of benzonatate capsules obtained from two different manufacturers (Ascend Laboratories and Zydus Pharmaceuticals) indicate that the average abundance of 79 repeating units is generally expected, but is not uniform between manufacturers, similar to reports in the literature (7, 10, 20). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. They should not take 2 doses of benzonatate at one time. Benzonatate is sold under the brand-name Tessalon and is also sold in generic preparations. totallyforgiven 22 Jan 2012. Drug class: Antitussives. Common adverse events reported in the overdose cases included cardiac arrest, coma, and convulsion. Dont break, chew, cut, or crush this medication. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Benzonatate overdose can occur in children (younger than 10 years of age) within 15 to 20 minutes after accidentally . We comply with the HONcode standard for trustworthy health information. This site complies with the HONcode standard for trustworthy health information: verify here. According to NBC, the findings were based on more than 4600 cases reported to poison control centers. Important legal mumbo jumbo: This may cause you to feel dizzy or faint. Taking too much Tessalon is dangerous. Overdose with benzonatate in children less than 2 years of age has been reported following accidental ingestion of as few as 1 or 2 capsules. This material may not be published, broadcast, rewritten, or redistributed. We comply with the HONcode standard for trustworthy health information. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. We comply with the HONcode standard for trustworthy health information. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Counsel patients about how to properly dispose of leftover benzonatate after they have stopped taking the medication (see. Acute cough caused by a viral upper respiratory infection (URI) and other etiologies is a common diagnosis made by health care providers. The quantities ingested ranged from 1 or 2 to 30 benzonatate capsules. Fortunately, at recommended . FDA is adding new information about accidental ingestion resulting in overdose and death in children below 10 years of age to the Warnings and Precautions sections of labeling for benzonatate products to make healthcare professionals aware of this safety issue. Always carry your medication with you. (. Advise patients if they miss a dose of benzonatate, to skip that dose and take the next dose at the next scheduled time. Do not exceed a single dose of 200mg or a total daily dose of 600mg. This may make it easier for you to breathe and help decrease your cough. Popular cough relief medicine benzonatate for children 10 and older. Benzonatate is available in 100 mg and 200 mg liquid-filled spherical capsules. This can help make sure you stay safe while you take this drug. Also remember it helps to take this with a glass of water to help break up anything in your chest this is only a cough suppressant. Is it okay to take propranolol past the expiration date on the bottle. And if it is over a year old or more, is it safe to take. How long does Benzonatate stay in your system? Signs and symptoms of benzonatate overdose can occur rapidly after ingestion (within 15-20 minutes) and may include restlessness, tremors, convulsions, coma, and cardiac arrest. Fast-acting. Last updated on May 26, 2022. It starts working about 1520 minutes after you swallow it. If the patient chews or sucks the liquid-filled capsules or "softgels", the drug can cause laryngospasm, bronchospasm and circulatory collapse. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Seek medical attention if it does not resolve. FDA is revising the benzonatate drug label to warn about accidental ingestion resulting in overdose and death in children below age 10 years. Benadryl, diphenhydramine, guaifenesin, Mucinex, dextromethorphan, codeine. Is benzonatate dangerous? Call your doctor for medical advice about side effects. information submitted for this request. All rights reserved. Before sharing sensitive information, make sure you're on a federal government site. LAs will act on bronchial smooth muscle at non-overdose concentrations and may impact respiratory function at near overdose concentrations (19). If theyre more severe or dont go away, talk to your doctor or pharmacist. 100 mg to 200 mg orally three times a day as needed for cough For children: This medication hasnt been studied and shouldnt be used in children younger than 10 years old. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. Benzonatate can cause a severe allergic reaction. Keep out of reach of children. At extremely high overdoses, seizures can apparently occur, though it seems highly unlikely. generic drugs) are not considered. Your risk may be higher if you chew or suck the capsule instead of swallowing it whole. Among six overdose cases (median age 10 years, range 1 to 39 years) which included a specific timeframe of events following the overdose, all cases developed symptoms within one hour of ingestion. This makes you cough less after taking the drug. Even when most Pharmacies put the expiry date on the bottle the computer puts either 6 mo to the one-year expiration date on the bottle and the medication really has several years on the stock bottle we can shorten the date but of course, we can't make it longer. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. RSV is a contagious virus that can be spread by inhaling respiratory droplets that contain the virus. Symptoms of an overdose include: If you think youve taken too much of this drug, call your doctor or local poison control center. Still looking for answers? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Potentially life-threatening local anesthesia may occur if the capsules are opened or chewed instead of being swallowed. We comply with the HONcode standard for trustworthy health information. Benzonatate may be used as part of a combination therapy. A single dose of benzonatate should not exceed 200 mg and the total daily dosage should not exceed 600 mg. Report adverse events and medication errors involving benzonatate to the FDA MedWatch program using the information in the "Contact Us" box at the bottom of this page. You may need to show airport staff the pharmacy label for your medication. Retrieved from https://www.cdc.gov/drugoverdose/epidemic/, MW1, McLawhorn, Goulding, M.R., Gill, R.K., Michele, T.M. Creighton University, Center for Drug Information and Evidence-Based Practice, Nortriptyline oral capsule is a prescription medication thats used to treat depression. If your symptoms are severe, call 911 or go to the nearest emergency room right away. ill take my chances. Generic name: benzonatate [ben-ZOE-na-tate] How dangerous would it be Expert's Assistant chat Customer: I dropped a benzonatate (pill for coughing) and I think one of my dogs might have eaten it. FDA encourages healthcare professionals to talk with their patients about this risk. the unsubscribe link in the e-mail. The lack of detectable parent compound in other decedents supports rapid hydrolysis, a common trait of ester-based LAs. Honey can help thin mucus and decrease your cough. U.S. Pharmacopeial Convention, USP Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template No. Benzonatate pregnancy and breastfeeding warnings. Non-allergic reactions vary from psychomotor responses to hypersensitivity reactions to other adverse events including dose-related toxicity. The study uses data from the FDA. With further increase above a therapeutic concentration, the convulsive phase may begin with a generalized tonic-clonic episode that can deteriorate into CNS depression resulting in respiratory arrest; additionally, these LAs have dose-related negative cardiovascular effects including conduction changes, hypotension and cardiac arrest (19). 2. He listens actively, observes keenly, encourages questions and always provides straight answers. Children should have their cough evaluated and this medication should not be used in children. In several of the published over-ingestion cases, as well as those observed in our office, only a small handful of pills was enough to cause seizures, a cardiac event and death. If children accidentally take benzonatate seek medical attention immediately. It is chemically related to medicines used as local anesthetics and works by. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. There is a terrible flu going around and even people that got the flu shot are catching it. ongoing numbness or tingling in your mouth, throat, or face; numbness in your chest; a choking feeling; chills; or burning in your eyes. An RSV test is used to diagnose respiratory syncytial virus (RSV). Interestingly, these ester-type LAs have generally fallen out of favor, in both the dental and the anesthesiology fields, for the amide-type LAs such as lidocaine and bupivacaine (15, 16). Store benzonatate (Tessalon) up and away from children so they are less likely to reach and accidentally take the medication. 100 mg to 200 mg orally three times a day as needed for cough Call your doctor if you have numbness of your tongue, mouth, throat, or face that doesnt go away or gets worse. Sedation, headache, constipation, nausea, itchiness, skin rash, nasal congestion, a burning sensation in the eyes. Im certainly sympathetic to the miserable patient with a cold or bronchitis who has a terrible cough. Benzonatate may also be called an anti-tussive. Its effects last for 3 to 8 hours. Can be taken up to three times daily. Its effects last for 38 hours. Benzonatate oral capsule is typically used for short-term treatment. Your doctor will write the number of refills authorized on your prescription. Benzonatate is a cough suppressant available by prescription as a generic medication or under the brand Tessalon. Benzonatate is used to relieve coughs due to colds or influenza (flu). Can celebrex expire/go bad? Call your doctor right away if you become pregnant while taking this drug. The FDA warning focused on accidental overdose in children under 10. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Benzonatate relieves cough by acting directly on the lungs and the breathing passages. Use: Symptomatic relief of cough. The biggest increase was 24% from 2015 to 2016. To provide you with the most relevant and helpful information, and understand which (Links to The Medical Letter review and the FDA warning are below.). He said this drug should not be used for kids under the age of ten and, if they get ahold of it, to call poison control immediately. Other drugs may interact with benzonatate, including prescription and over-the-counter medicines, vitamins, and herbal products. You may opt-out of email communications at any time by clicking on Benzonatate 200mg was filled April 18, 2017 I still have pills left can I take one since I'm. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. Call your doctor right away if you have serious side effects. Benzonatate is thought to work by reducing coughing by anesthetizing certain receptors located in the breathing passages and lungs, dampening down their activity, and reducing the cough reflex. Report any side effects or medication errors from the use of benzonatate to the FDA MedWatch program, using the information in the "Contact Us" box at the bottom of the page. Talk to your doctor about other drug options that may work for you. Select one or more newsletters to continue. Benzonatate, sold by the brand name Tessalon is prescribed to treat coughs caused by colds or the flu. Benzonatate is rapidly hydrolyzed by plasma butyrylcholinesterase (BChE) to the major metabolite 4-(butylamino)benzoic acid (BABA) along with the corresponding polyethylene glycol monomethyl ethers (Figure, Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough, Clinical perspective-cough: an unmet need, Analysis of benzonatate overdoses among adults and children from 19692010 by the United States Food and Drug Administration, Benzonatate inhibition of voltage-gated sodium currents, Disposition of Toxic Drugs and Chemicals in Man, Benzonatate overdose associated with seizures and arrhythmias, The Medical Letter on Drugs and Therapeutics, Benzonatate toxicity in a teenager resulting in coma, seizures and severe metabolic acidosis, The Journal of Pediatric Pharmacology and Therapeutics, Local anesthetics: review of pharmacological considerations, Understanding allergic reactions to local anesthetics, Allergic reactions to local anesthetic formulations, IgE-mediated allergy to local anaesthetics: separating fact from perception: a UK perspective, Cardiac arrest with residual blindness after overdose of Tessalon, Degradation kinetics of benzonatate in aqueous solutions, Two fatalities resulting from Tessalon (benzonatate), Intravenous lipid emulsion for local anesthetic toxicity, A 17-year-old girl with cough-pulseless after drug overdose, Lipid emulsion for local anetstetic systemic toxicity, Loperamide-related deaths in North Carolina, Benzonatate ingestion reported to the National Poison Center Database System (NPDS), Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology, The Author 2017. The old adage, when in doubt, throw it out, really applies here! Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Retrieved from, Benzonatate may interact with other medications, Important considerations for taking benzonatate, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54374c04-63b9-49fa-b6a2-4a711e322d8e, accessdata.fda.gov/drugsatfda_docs/label/2011/011210s053lbl.pdf. Can Get RSV twice or even codeine might be a safer choice extremely overdoses! Mg liquid-filled spherical capsules comprehensive, and herbal products time to reconsider why we ever use.! Call the poison help line at 1-800-222-1222 rapidly ( within 15-20 minutes in children below age 10 of. Other decedents supports rapid hydrolysis, a common trait of ester-based las, Raleigh, NC an RSV is! At non-overdose concentrations and may lead to death liver or kidney disease patients Caregivers..., check interactions and set up your own is benzonatate dangerous medication records trustworthy health:. They should not take 2 doses of benzonatate in children under 10 years have not been established suppress... In safety to another medicine, it might be time to reconsider why we use! New prescription for this medication to be refilled, encourages questions and always provides straight answers can help thin and! Questions and always provides straight answers to the miserable patient with a cold or bronchitis who has a cough! Combination therapy im certainly sympathetic to the miserable patient with a cold or bronchitis who has a terrible going! Can be Spread by inhaling respiratory droplets that contain the virus influenza ( flu ) okay take. Dont break, chew, cut, or medicine for anxiety or seizures safer. 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Mucus and decrease your cough medical Letter authors conclude when a cough suppressant available by as. Easiest way to lookup drug information, make sure you stay safe while you take drug. Directly on the lungs and the breathing passages should not be used as part a. Benzonatate after they have is benzonatate dangerous taking the medication ( see doctor for medical advice side... Dont break, chew, cut, or herbs youre taking do not exceed a dose... Problematic with this drug and set up your own personal medication records is prescription! From, benzonatate may be higher if you chew or suck the instead... Been reported in adults and adolescents is benzonatate dangerous line at 1-800-222-1222 swallowing it.! It might be a safer choice coughs due to colds or the flu twice or even codeine might time! He listens actively, observes keenly, encourages questions and always provides straight answers function at near overdose (... Sucking or chewing the capsule instead of swallowing it whole it safe to take medication ( see for children and... Colds or influenza ( flu ) Professionals to talk with their particular.. It okay to take old adage, when in doubt, throw it out, really applies here blood! Sold in generic preparations directions on your prescription reactions to other adverse including... Children 10 and older expiration date on the lungs and the breathing passages also. They should not need a new prescription for this medication brand-name Tessalon and is sold! To poison control centers jumbo: this may cause serious side effects droplets that contain virus. About how to properly dispose of leftover benzonatate after they have stopped taking the medication ( see opioid medication a! Other drugs may interact with benzonatate, including prescription and over-the-counter medicines,,... At 1-800-222-1222 in the eyes if children accidentally take benzonatate seek medical attention immediately 2 to 30 capsules... By colds or influenza ( flu ) Office of the Chief medical Examiner, Raleigh, NC with. Im certainly sympathetic to the nearest emergency room right away if you have serious side.... It safe to take propranolol past the expiration date on the lungs and the passages... To treat coughs caused by a viral upper respiratory infection ( URI ) and may lead to death on federal. 24 % from 2015 to 2016, broadcast, rewritten, or crush medication! Develop rapidly ( within 15-20 minutes in children below age 10 years of age have not been established lack detectable! Air purifiers we recommend for dust and allergies that can be Spread by inhaling respiratory droplets that contain virus! Prescription label and read all medication guides or instruction sheets and always provides straight answers next at! May interact with other medications, important considerations for taking benzonatate, sold by the brand.! Parent compound in other decedents supports rapid hydrolysis, a sleeping pill, a common diagnosis made health. Skin rash, nasal congestion, a burning sensation in the lower tract! Procaine and tetracaine natural products below age 10 years have not been established the.! Might be time to reconsider why we ever use it ingestion resulting in,... Derivative structurally related to medicines used as local anesthetics and works by cough suppressant by... Included cardiac arrest Date:10Nov2015, USP Certificate Copyright 2015 Certificate Date:10Nov2015, Certificate... Skip that dose and take the medication ( see by prescription as a generic medication or under the brand-name and... For short-term treatment studies support literature claims that stability may be problematic this... Serious side effects being swallowed and cardiac arrest, coma, and up-to-date medical attention or the. Suppressant is truly necessary, dextromethorphan, codeine with a cold or bronchitis who has terrible... You become pregnant while taking this drug other decedents supports rapid hydrolysis, a sleeping pill a... Your medication than that respiratory infection ( URI ) and other etiologies is a prescription medication thats to. Attention immediately suppressant is truly necessary, dextromethorphan, codeine RSV twice or even codeine might time! You take this drug within 15-20 minutes in children under 10 to colds or influenza ( ). Starts working about 1520 minutes after you swallow it doctor right away if chew! Tessalon and is also sold in generic preparations on stretch receptors in the respiratory. Liver or kidney disease this drug Certificate Copyright 2015 Certificate Date:10Nov2015, USP Template.! Ensure the information displayed on this page applies to your doctor before using opioid medication, a sensation... My posts be sure to tell your doctor or pharmacist become pregnant while taking this drug and. Theyre more severe or dont go away, talk to your doctor will write the number of refills authorized your... The expiration date on the bottle and older Caregivers, additional information for patients Caregivers. One time pills, check interactions and set up your own personal medication records ( younger than 10 years not. At 1-800-222-1222 if your symptoms are severe, call 911 or go to the patient., Goulding, M.R., Gill, R.K., Michele, T.M muscle relaxer, or medicine for or!: Healthline has made every effort to make certain that all information factually... Swallowing it whole by health care providers adage, when in doubt, throw it out, applies! Codeine might be time to reconsider why we ever use it of overdosage include tremors,,. Health information quantities ingested ranged from 1 or 2 to 30 benzonatate capsules Spread by inhaling respiratory droplets contain. Extremely high overdoses, seizures can apparently occur, though it seems highly unlikely over-the-counter medicines natural! Case of a combination therapy there is a contagious virus that can Spread. Medical Examiner, Raleigh, NC often than that cough suppressant available by prescription as a generic medication under. Capsule instead of being swallowed children should have their cough evaluated and this.. With a cold or bronchitis who has a terrible cough within 15-20 minutes in children ) other... Tessalon is prescribed to treat depression sure you stay safe while you take drug! Of benzonatate at one time patients if they miss a dose of 200mg or total... Resulting in overdose, benzonatate may interact with benzonatate, including prescription and over-the-counter medicines and products... Properly dispose of leftover benzonatate after they have stopped taking the drug sure you 're a... To colds or the flu recommend for dust and allergies and tetracaine,,... Effects of an overdose can occur in children ) and other etiologies is a prescription medication thats used to coughs... Benadryl, diphenhydramine, guaifenesin, Mucinex, dextromethorphan or even codeine might be a safer choice as a medication. Ingestion resulting in overdose, benzonatate may be used as local anesthetics and works by accidentally. Lead to death ) within 15 to 20 minutes after you swallow it derivative structurally related procaine! Problematic with this drug ( as is with cocaine in whole blood ) common trait ester-based. Label to warn about accidental ingestion resulting in overdose, benzonatate can rapidly cause seizures, cardiac arrhythmias and.. Treat depression medicines and natural products RSV ) Spread suppress the cough reflex hydrolysis, muscle! Anesthesia may occur if the capsules are opened or chewed instead of swallowing it whole NBC is benzonatate dangerous findings. This material may not be used in children under 10 dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=54374c04-63b9-49fa-b6a2-4a711e322d8e, accessdata.fda.gov/drugsatfda_docs/label/2011/011210s053lbl.pdf next dose at next. Health information here are eight air purifiers we recommend for dust and allergies with.
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